Airway mucin secretion is important pathophysiologically and as a model of polarized epithelial regulated exocytosis. We find the trafficking protein, SNAP23, selectively expressed in secretory cells compared with ciliated and basal cells of airway epithelium by immunohistochemistry and FACS, suggesting that SNAP23 functions in regulated but not constitutive epithelial secretion. Heterozygous SNAP23 deletant mutant mice show spontaneous accumulation of intracellular mucin, indicating a defect in baseline secretion. However mucins are released from perfused tracheas of mutant and wild-type mice at the (...) same rate, suggesting that increased intracellular stores balance reduced release efficiency to yield a fully compensated baseline steady state. In contrast, acute stimulated release of intracellular mucin from mutant mice is impaired whether measured by a static imaging assay 5 min after exposure to the secretagogue ATP or by kinetic analysis of mucins released from perfused tracheas during the first 10 min of ATP exposure. Together, these data indicate that increased intracellular stores cannot fully compensate for the defect in release efficiency during intense stimulation. The lungs of mutant mice develop normally and clear bacteria and instilled polystyrene beads comparable to WT mice, consistent with these functions depending on baseline secretion that is fully compensated. (shrink)

Burton F. Porter explores the philosophical question of the existence of God in an open, yet critical, way, examining the argumentation used by centuries of human society to support or reject divinity.

What the Tortoise Taught Us offers a lively, concise journey through western philosophy that explores the lives of major philosophers, their ideas, and how their thinking continues to influence our lives today.

What the Tortoise Taught Us offers a lively, concise journey through western philosophy that explores the lives of major philosophers, their ideas, and how their thinking continues to influence our lives today.

Prof. Burton Porter surveys philosophy and ethics in a clear, concise way, examines our present attitudes and values, and offers signposts for a successful life. With full, 21st century awareness, the author points to dimensions of human beings that can be realized to create a fulfilling existence.

This book describes the "naturalistic fallacy", as attributed to Hume, that non-moral premises cannot logically entail a moral conclusion, and distinguishes it from the similarly named though subtly different fallacy identified by Moore in Principia Ethica by comparing and contrasting its presence in a range of ethical or moral systems. A review of Hume’s position elicits the implications to theological naturalism, and how this relates to Kierkegaard’s "paradox of faith" and the doctrine of ineffability. Methods of logical examination of religious (...) language are discussed, leading to the dissection of the analytic proposition that ‘God is Good’ and of the connotations of proper names. Porter concludes from this a solution to the naturalistic fallacy: that "good" is essential to "God" by definition, and therefore that premises relating to God must contain an inherent morality. Originally published in 1968, this book includes topics such as Mediaeval attitudes to deity and morality; Religious myth, images and language; Comparative conceptions of deity. (shrink)

Introduction: The spectrum and the poles -- Seeking truth or pursuing happiness -- Just deserts or divine forgiveness -- Our conduct as forced or free -- Religious faith and rational doubt -- Individual rights and the common good -- Human I.Q. and animal feeling -- Asceticism and sensuality -- The populist and elitist perspectives -- Self-interest and self-sacrifice -- Truth as invented or discovered -- Men and women : categories or constructs -- Trusting our senses or being rational -- Northern (...) efficiency and Southern charm. (shrink)

The Fundamentals of Ethics is a textbook that introduces students to the central ideas of moral philosophy in a thorough yet compact and engaging way. It contains several chapters each on The Good Life, Normative Ethics, and Metaethics. It has greater breadth and depth than Rachels' The Elements of Moral Philosophy, offering a substantial level of analysis while also keeping the student reader in mind. Writing in a lively style with many examples, the author reconstructs and carefully evaluates over forty (...) central arguments in moral philosophy, helping students to improve their critical thinking skills along the way. It is designed to be used on its own or in conjunction with The Ethical Life, the companion reader. (shrink)

We extend the Theory of Planned Behavior (TPB) for ethics in the workplace. Using a path modeling methodology, we find evidence that, for ethics, moral disengagement is an antecedent to the TPB predictors of attitude, subjective norms, and perceived behavioral control (PBC). We show that the TPB predictors mediate the influence moral disengagement has on ethical behavioral intentions. Thus, to improve ethical behavior, reducing moral disengagement is critical. We find support for including both types of PBC (self-efficacy and locus of (...) control) when modeling ethical behavior. We use four ethics scenarios and international data to test this model. We also evaluate potential positive influences on ethics in the workplace and find that recency of ethics training interacts with religiosity and activates it to reduce moral disengagement. We also find that principles-based ethics training enhances professionals’ self-efficacy to behave ethically. Experience, including time as a member in a professional accounting organization, increases both locus of control and self-efficacy to behave ethically. These variables—recency of ethical training, religiosity, principles-based professional ethics training, and experience—influence parts of the core TPB model, which in turn lead to improved ethical behavioral intentions. (shrink)

This book describes the "naturalistic fallacy", as attributed to Hume, that non-moral premises cannot logically entail a moral conclusion, and distinguishes it from the similarly named though subtly different fallacy identified by Moore in Principia Ethica by comparing and contrasting its presence in a range of ethical or moral systems. A review of Hume’s position elicits the implications to theological naturalism, and how this relates to Kierkegaard’s "paradox of faith" and the doctrine of ineffability. Methods of logical examination of religious (...) language are discussed, leading to the dissection of the analytic proposition that ‘God is Good’ and of the connotations of proper names. Porter concludes from this a solution to the naturalistic fallacy: that "good" is essential to "God" by definition, and therefore that premises relating to God must contain an inherent morality. Originally published in 1968, this book includes topics such as Mediaeval attitudes to deity and morality; Religious myth, images and language; Comparative conceptions of deity. (shrink)

Intended for use in the introduction to ethics course, this text is designed to engage today's practical-minded student in more fundamental questions. The book ranges from ideals in living to contemporary moral problems, exploring and analyzing both areas in order to stimulate deeper reflection.

A philosophical analysis is offered of the relationship between knowledge and liberation in Buddhism. Buddhists often consider the knowledge of impermanence as a key to liberation from craving, attachment, and hence suffering. However, it can be objected that one may know that things are impermanent and yet still be subject to craving and attachment. In the face of this objection, critical consideration is given to five ways in which one might preserve the claim that a knowledge of things as they (...) actually are results in liberation from craving and attachment. Many Buddhists might in fact reject the thesis that knowledge alone, no matter how it is characterized, is a sufficient condition for liberation. (shrink)

Lively, comprehensive, and contemporary, The Voice of Reason: Fundamentals of Critical Thinking covers three principal areas: thought and language, systematic reasoning, and modes of proof. It employs highly accessible explanations and a multitude of examples drawn from social issues and various academic fields, showing students and other readers how to construct and criticize arguments using the techniques of sound reasoning. The Voice of Reason examines the traditional elements of the field and also explores new ground. The first section of the (...) book elucidates the relationship between thought and language, explaining how words function. It discusses meaning, connotation, vagueness, ambiguity, and definition, identifying the linguistic elements that can produce mistakes in thinking. The next section describes the rules of systematic reasoning, examining such topics as truth, relevance, and adequacy; deductive logic ; and induction. Sixteen fallacies in thinking are also described through extensive illustrations and applications. The final section of the book offers a unique study of what constitutes proof in several different areas--including politics, advertising, law, and social issues--as well as in the academic disciplines of literature, science, history, and ethics. The author describes the various rules of evidence, using essays by major figures in each field as examples. An ideal text for courses in critical thinking, informal logic, and reasoning and writing, The Voice of Reason offers numerous pedagogical features including a host of examples; assignments, exercises, and puzzles at both the halfway point and at the end of each chapter; cartoons and quotations throughout; and practical applications of theoretical concepts. An extensive Instructor's Manual contains answers to the exercises that appear throughout the text. (shrink)

The text consists of essays that revolve around the question of the nature and meaning of philosophy, even as it demonstrates philosophy's significance and relevance to some fundamental human problems and issues. The essays present diverse views of what philosophy might be and might aspire to be, with contributors being influenced by a wide range of philosophical approaches and traditions. The conversations also cut across disciplinary boundaries to interrogate and utilize ideas taken from ethics, epistemology, metaphysics, literary studies, cultural studies, (...) and the sociology of science. Traversing regional boundaries, the essays show philosophical analysis at work in exploring some issues pertinent to African, Caribbean, European, and American experiences, even while not ignoring Asian traditions. The collection presents interesting and intriguing views on how philosophical inquiry can illuminate various pressing problems: development, conflict, the discriminating preservation of worthwhile traditions, and the prevalence of apathy. It also reflects the vitality and multifaceted nature of philosophical discourse in grappling with live issues. The edited text is a comprehensive, balanced, and unique anthology of readings capturing the diversity of philosophical investigation. (shrink)

The Southern Transjordan Edomite Plateau and the Dead Sea Rift Valley: The Bronze Age to the Islamic Period. By Burton MacDonald. Oxford: Oxbow Books, 2015. Pp. ix + 118, 49 pls. $120.

Emptiness Appraised. A Critical Study of Nagarjuna's Philosophy. David F. Burton. Curzon Press, Richmond 1999. XV, 233 pp. £40.00. ISBN 0 7007 1066 3.

This major addition to the series of Cambridge Texts in the History of Political Thought seeks to give students with no specialist knowledge access to both the practical and the metaphysical aspects of Hegel's political thought. The ethical and metaphysical texts in this collection both illuminate and contrast with those political and historical texts in which Hegel draws important conclusions about the modern world from remarkable comparative analyses of recent developments in England, France and Germany. The translator of these texts, (...) H. B. Nisbet, was responsible for the acclaimed rendition of Hegel's Philosophy of Right already published in this series, and Lawrence Dickey's lucid editorial commentary introduces this distinctive corpus of political writing by one of the very greatest thinkers in the European tradition. A full chronology, explanatory annotation, glossary and bibliography are appended to aid the student reader. (shrink)

Researchers have identified the phenomena of moral distress through many studies in Western countries. This research reports the first study of moral distress in Iran. Because of the differences in cultural values and nursing education, nurses working in intensive care units may experience moral distress differently than reported in previous studies. This research used a qualitative method involving semistructured and in-depth interviews of a purposive sample of 31 (28 clinical nurses and 3 nurse educators) individuals to identify the types of (...) moral distress among clinical nurses and nurse educators working in 12 cities in Iran. A content analysis of the data produced four themes to describe the nurses’ moral distress. The four themes were as follows: (a) institutional barriers and constraints; (b) communication problems; (c) futile actions, malpractice, and medical/care errors; (d) inappropriate responsibilities, resources, and competencies. The results demonstrate that moral distress for intensive care unit nurses is different and that the nursing leaders must reduce moral distress among nursing in intensive care. (shrink)

Local food systems can have economic and social benefits by providing income for producers and improving community connections. Ongoing global climate change and the acute COVID-19 pandemic crisis have shown the importance of building equity and resilience in local food systems. We interviewed ten stakeholders from organizations and institutions in a U.S. midwestern city exploring views on past, current, and future conditions to address the following two objectives: 1) Assess how local food system equity and resilience were impacted by the (...) COVID-19 pandemic, and 2) Examine how policy and behavior changes could support greater equity and resilience within urban local food systems. We used the Community Capitals Framework to organize interviewees’ responses for qualitative analyses of equity and resilience. Four types of community capital were emphasized by stakeholders: cultural and social, natural, and political capital. Participants stated that the local food system in this city is small; more weaknesses in food access, land access, and governance were described than were strengths in both pre- and post-pandemic conditions. Stakeholder responses also reflected lack of equity and resilience in the local food system, which was most pronounced for cultural and social, natural and political capitals. However, local producers’ resilience during the pandemic, which we categorized as human capital, was a notable strength. An improved future food system could incorporate changes in infrastructure (e.g., food processing), markets (e.g., values-based markets) and cultural values (e.g., valuing local food through connections between local producers and consumers). These insights could inform policy and enhance community initiatives and behavior changes to build more equitable and resilient local food systems in urban areas throughout the U.S. Midwest. (shrink)

My apology for reverting to this subject is a recent article by Mr. W. C. F. Walters in the April number of the Classical Quarterly for 1910 on the signatures in the Vatican Codex . Mr. Walters does not seem to have been aware that this manuscript, though not of direct value in the constitution of the text of Livy, is one whose interest from a palaeographical point of view has long been recognized. A number of articles have been written (...) concerning it, most of which deal with the signatures, the subject of Mr. Walters' paper, more fully and more accurately than he has done. Beyond giving the signatures, two of them incorrectly, Walters does nothing more than to conclude that there were eight scribes, who copied 42 quaternions. But a great deal more than this is known about the scribes and the manuscript. In fact, thanks to the ingenious combinations of Chatelain and Traube in piecing together the hints suggested by the signatures, more is known about this particular manuscript and the circumstances under which it was made than is the case with any other manuscript of a classical author of so early a date. It may therefore be worth while to summarize the known data concerning the manuscript, with a brief account of how they were worked out, referring the reader for the details to the articles mentioned in the footnotes. (shrink)

In the years following the COVID‐19 pandemic, issues such as high job demands, burnout, and turnover continue to influence the nursing workforce, with heavier impacts to marginalized groups. Understanding the work and life contexts of nurses of color can help guide strategies for workplace equity and meaningful support. This qualitative study explored the experiences of nurses of color in the United States during the pandemic, focusing on feelings about the profession and job decisions. The overarching theme was “answering the call,” (...) with subthemes of “COVID shone a light,” “being consumed by COVID,” and “is it worth it?” Participants shared how their racial identities shaped their perceptions and job decisions in positive and negative ways, noting how racism impacted many facets of their work and added to the stressors felt in the workplace and the community. Findings provide insight into the underrepresented perspectives of nurses of color and suggest strategies to eliminate racism in nursing. (shrink)

Western societies today are coming unmoored in the face of an earth-shaking ethical and cultural paradigm shift. At its core is the question of what it means to be human and how we are meant to live. The old answers are no longer accepted; a dizzying array of options are offered in their stead. Underpinning this smorgasbord of lifestyles is a thicket of unquestioned assumptions, such as the separation of gender from biological sex, which not so long ago would have (...) been universally rejected as radical notions. In the spring of 2019, a group of Orthodox Christian scholars drawn from a wide variety of academic disciplines met together to offer responses to the moral crisis our generation faces, elaborating upon its various forms and facilitating a fuller understanding of some of its theological and philosophical foundations. In doing so they offer support to all those who question the claims that are so forcefully insisted upon today--a clarity that will aid them in standing up and resisting trends that have already shown to be the cause of great suffering and unhappiness. (shrink)

This article aims to offer a fresh analysis of two passages in the extensive necromancy episode in Lucan's Bellum Ciuile: the ritual to reanimate the dead soldier's corpse (6.667–73), and the surgical procedure Erichtho then proceeds to undertake (6.750–7), resembling the practice of a vivisection. The study will focus mostly on the strong connection of magic to medical traditions in antiquity, with a commentary on, and analysis of, these verses through the lenses of medical vocabulary, themes and motifs. It ultimately (...) concludes that Lucan was familiar with the language and characteristics of the medical tradition, enriched his report with them, and was playing with his audience's knowledge of the same. (shrink)

The aim of this short note is to highlight a possible, hitherto unnoticed, telestich in Verg. Aen. 8.246–9, which presents the Greek word sēma (‘portent’, ‘wonder’, ‘prodigy’, ‘tomb’). To justify this identification, I will argue for its significance from its context in the poem (the battle between Hercules and Cacus), pointing out the insistence on the imagery of light and revelation, and the use of the phrase mirabile dictu, which appears in the same episode of the Aeneid, in the Latin (...) poetic tradition. (shrink)